Cardiovascular disease and excess mortality in depression: physical activity as a game changer

Problem: Depression is a widespread disorder and among the leading causes of disability worldwide. In this article, we perform an umbrella review on association between depression excess mortality, cardiovascular disease (CVD), risk factors. We also provide overview mechanisms that explain these associations. Finally, discuss clinical implications from general perspective potential physical activity to favorably influence relationship premature mortality. Methods: Meta-analyses were identified via PubMed. Only works unipolar included. Results: The mortality robust epidemiological finding. This can be attributed fact people with are at increased for CVD accumulate more However, causal associations complex. While associated incident CVD, consequence cardiac events. Regular higher cardiorespiratory fitness levels mitigate depression. Discussion: More attention should paid health psychiatric patients. High priority given promotion fitness, as they beneficial both mental health. Key Words: Fitness, Cardiovascular Disease, Physical Activity, Mortality